A Clinical Study of ONCT-808 in Subjects With Relapsed or Refractory B-Cell Malignancies

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

May 9, 2023

Primary Completion Date

September 12, 2024

Study Completion Date

September 12, 2024

Conditions
Relapsed/Refractory Aggressive B-Cell Malignancies
Interventions
BIOLOGICAL

ONCT-808

"A single infusion of ONCT-808 autologous CAR-T cell infusion will be administered intravenously~Phase 1: Dose Escalation with bridging therapy as needed~Phase 2: Patients with LBCL or MCL will be enrolled into two separate dose expansion cohorts."

DRUG

Bridging Therapy

Bridging therapy can be oral chemotherapy or IV radiotherapy/chemotherapy per institution's guidelines

Trial Locations (4)

77030

The University of Texas MD Anderson Cancer Center, Houston

91010

City of Hope National Medical Center, Duarte

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

Sponsors
All Listed Sponsors
lead

Oncternal Therapeutics, Inc

INDUSTRY

NCT05588440 - A Clinical Study of ONCT-808 in Subjects With Relapsed or Refractory B-Cell Malignancies | Biotech Hunter | Biotech Hunter