taVNS for FRNS in Children

NARecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 5, 2023

Primary Completion Date

August 1, 2025

Study Completion Date

August 1, 2025

Conditions
Nephrotic Syndrome in ChildrenMinimal Change DiseaseFocal Segmental Glomerulosclerosis
Interventions
DEVICE

Transcutaneous auricular vagus nerve stimulation

The device to be used is the Roscoe Medical TENS 7000, a commercially available handheld electrical pulse generator, and an ear clip to be placed at the left ear for stimulation. Custom-made ear clips with electrode gel will be placed near the entrance to the canal of the ear to provide stimulation to the auricular branch. The handheld electrical pulse generator will be programmed to deliver electrical stimulation pulses to the cymba concha stimulating the auricular branch of the vagus nerve.

DEVICE

Sham device

The device will appear to function but no electrical stimulation will be delivered.

Trial Locations (2)

11040

RECRUITING

Cohen Children's Medical Center, New Hyde Park

19102

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

Northwell Health

OTHER