A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

November 14, 2023

Primary Completion Date

July 31, 2028

Study Completion Date

July 31, 2028

Conditions
Multiple Myeloma
Interventions
DRUG

Cevostamab

"Substudy 2: Cevostamab will be administered intravenously (IV) on a 28-day cycle, up to a total of 13 cycles.~Substudy 4: Cevostamab will be administered by IV on a 21-day cycle, up to a total of 17 cycles."

DRUG

Lenalidomide

Lenalidomide will be administered PO on days 1-21 of a 28-day cycle.

DRUG

Tocilizumab

Tocilizumab will be administered for the treatment of cytokine release syndrome (CRS) when necessary.

DRUG

Iberdomide

Iberdomide will be administered PO on days 1-14 of a 21-day cycle.

DRUG

Dexamethasone

Dexamethasone will be administered on Days 2 and 8 of Cycles 1-3.

Trial Locations (16)

2031

RECRUITING

Prince of Wales Hospital, Randwick

3065

RECRUITING

St Vincent's Hospital Melbourne, Fitzroy

20246

RECRUITING

Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II, Hamburg

28040

RECRUITING

Fundacion Jimenez Diaz, Madrid

31059

RECRUITING

IUCT Oncopole, Toulouse

37044

RECRUITING

Hopital Bretonneau, Tours

46010

RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

69310

RECRUITING

CHU Lyon Sud - Service Hématologie, Pierre-Bénite

94800

WITHDRAWN

IGR, Villejuif

04103

RECRUITING

Universitätsklinikum Leipzig - Klinik und Poliklinik für Hämatologie, Leipzig

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gda?sk

10-228

RECRUITING

Oddzial Kliniczny Hematologii SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie, Olsztyn

60-569

RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu, Późna

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08915

RECRUITING

Hospital Universitari Germans Trias i Pujol, Badalona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY