Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial

NARecruitingINTERVENTIONAL
Enrollment

3,000

Participants

Timeline

Start Date

July 3, 2023

Primary Completion Date

January 1, 2025

Study Completion Date

November 30, 2025

Conditions
Preeclampsia
Interventions
DRUG

75 mg acetylsalicylic acid

75 mg acetylsalicylic acid (C9H8O4, CAS number 50-78-2) daily, Oral

DRUG

1.5g Metformin

up to 1.5 g metformin (C4H11N5, CAS number 657-24-9) daily, Oral Dose increases from 0.5g to 1.0g to 1.5g

DRUG

150 mg acetylsalicylic acid

150 mg acetylsalicylic acid (C9H8O4, CAS number 50-78-2) daily, Oral

DRUG

Placebo of acetylsalicylic acid and Metformin

Pills with shape, color and smell same with acetylsalicylic acid and metformin, daily, oral

Trial Locations (6)

Unknown

RECRUITING

Peking University First Hospital, Beijing

WITHDRAWN

Guangzhou Women and Children's Medical Center, Guangzhou

NOT_YET_RECRUITING

The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou

RECRUITING

Obstetrics and Gynecology Hospital of Fudan University, Shanghai

RECRUITING

Shanghai First Maternity and Infant Hospital, Shanghai

RECRUITING

West China Second University Hospital, Sichuan University, Chengdu

All Listed Sponsors
collaborator

Obstetrics & Gynecology Hospital of Fudan University

OTHER

collaborator

Shanghai First Maternity and Infant Hospital

OTHER

collaborator

West China Second University Hospital

OTHER

collaborator

Peking University First Hospital

OTHER

lead

Chinese University of Hong Kong

OTHER