A Clinical Study of MK-1045 (CN201) in People With Precursor B-cell Acute Lymphoblastic Leukemia (MK-1045-002)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

203

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Acute Lymphoblastic Leukemia
Interventions
DRUG

MK-1045

MK-1045 is administered by IV infusion once a week (QW), 4 weeks per treatment cycle, starting with 2 cycles of induction treatment. After a 2-week treatment-free interval, responders to induction treatment receive 3 cycles of consolidation therapy, and up to 7 cycles of maintenance treatment or until intolerable toxicity, disease progression, withdrawal of informed consent, loss to follow-up, receipt of other antitumor therapy, or death, whichever occurs first. Each 4 week treatment cycle is followed by a 2-week treatment-free interval

Trial Locations (11)

150010

RECRUITING

The First Hospital of Harbin ( Site 0005), Harbin

221006

ACTIVE_NOT_RECRUITING

The Affiliated Hospital of Xuzhou Medical University ( Site 0007), Xuzhou

301617

RECRUITING

Hematology Hospital of Chinese Academy of Medical Sciences ( Site 0001), Tianjin

310003

COMPLETED

The Children's Hospital of Zhejiang University School of Medicine ( Site 0009), Hangzhou

400037

RECRUITING

The Second Affiliated Hospital of Third Military Medical University ( Site 0008), Chongqing

430022

RECRUITING

Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology ( Site 0010), Wuhan

430030

RECRUITING

Tongji Hospital affiliated to Tongji Medical College of HUST ( Site 0006), Wuhan

450008

RECRUITING

Henan Cancer Hospital-hematology department ( Site 0002), Zhengzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital ( Site 0004), Guangzhou

610000

COMPLETED

West China Second University Hospital, Sichuan University ( Site 0011), Chengdu

050000

RECRUITING

The Second Hospital of Hebei Medical University ( Site 0003), Shijiazhuang

All Listed Sponsors
lead

MSD R&D (China) Co., Ltd.

INDUSTRY