A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

July 14, 2023

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
Multiple MyelomaNeoplasmsNeoplasm, Plasma CellGammopathy, MonoclonalParaproteinemiasBlood Protein DisordersHaematologic DiseaseCorneal Disease
Interventions
DRUG

Belantamab Mafodotin-Blmf

Blmf will be available as 100 mg/vial in single-use vial for reconstitution, supplied as lyophilized powder. Blmf will be delivered as IV solution over at least 30 minutes.

DRUG

Lenalidomide

Lenalidomide will be administered per os.

DRUG

Dexamethasone

Dexamethasone will be administered intravenously or per os.

DRUG

Nirogacestat

Nirogacestat will be administrated each day for all subsequent cycles were Blmf is also administrated.

Trial Locations (2)

11528

RECRUITING

"General Hospital of Athens Alexandra, NKUA, Therapeutic Clinic", Athens

54639

NOT_YET_RECRUITING

"Anticancer Hospital of Thessaloniki Theageneio", Thessaloniki

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Hellenic Society of Hematology

OTHER