TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

March 1, 2023

Primary Completion Date

December 30, 2026

Study Completion Date

December 30, 2026

Conditions
Breast Cancer
Interventions
DRUG

ARV-471

Daily oral dosages of ARV-471 continuously, dose escalation/de-escalation in Phase 1b until RP2D determined, cycles lasting 28 days

DRUG

Ribociclib

Daily oral dosages of ribociclib consecutively for 21 days followed by 7 days off treatment, cycles lasting 28 days

Trial Locations (29)

20900

Fondazione IRCCS San Gerardo dei Tintori, Monza

28041

Hospital Universitario 12 de Octubre, Madrid

33607

Moffitt Cancer Center - International Plaza, Tampa

33612

Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center, Tampa

Moffitt Cancer Center, Tampa

Moffitt McKinley Hospital, Tampa

41013

Hospital Universitario Virgen Del Rocio, Seville

62269

Siteman Cancer Center - WUPI, Shiloh

63031

Siteman Cancer Center - North County, Florissant

63108

Siteman Cancer Center, St Louis

63110

Barnes Jewish Hospital Department of Laboratories, St Louis

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine - Siteman Cancer Center, St Louis

Washington University School of Medicine, St Louis

63129

Barnes Jewish Hospital Lab- South County, St Louis

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St Peters, City of Saint Peters

94158

UCSF Medical Center at Mission Bay, San Francisco

94304

Stanford Women's Cancer Center, Palo Alto

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

02459

Dana-Farber Cancer Institute - Chestnut Hill, Newton

V5Z 1H7

BC Cancer Vancouver, Vancouver

V5Z 4E6

BC Cancer Vancouver, Vancouver

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M4N 3M5

Sunnybrook Research Institute, Toronto

G7H 5H6

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi

H3T 1E2

Jewish General Hospital, Montreal

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Arvinas Estrogen Receptor, Inc.

INDUSTRY

lead

Pfizer

INDUSTRY

NCT05573555 - TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) | Biotech Hunter | Biotech Hunter