Study to Determine the Maximum Tolerated Dose (MTD) of PARPi 2X-121 Monotherapy and the MTD of Dovitinib in Combination With 2X-121 in Patients With Advanced Solid Tumors

PHASE1SuspendedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

February 20, 2023

Primary Completion Date

October 1, 2024

Study Completion Date

December 31, 2025

Conditions
Advanced Solid Tumors
Interventions
DRUG

2X-121 and dovitinib

"The dose levels to be evaluated in Part 1 are:~Cohort 1 600 mg (morning dose: 200 mg + evening dose: 400 mg); Cohort 2 800 mg (morning dose: 400 mg + evening dose: 400 mg); Cohort 3 1000 mg (morning dose: 400 mg + evening dose: 600 mg);~The dose levels to be evaluated in Part 2 are:~Cohort 1 2X-121 (MTD) + 300 mg dovitinib; Cohort 2 2X-121 (MTD) + 400 mg dovitinib; Cohort 3 2X-121 (MTD) + 500 mg dovitinib;"

Trial Locations (2)

28078

Carolina BioOncology, Huntersville

44106

University Hospitals Cleveland Medical Center, Cleveland

Sponsors
All Listed Sponsors
collaborator

Amarex Clinical Research

OTHER

lead

Allarity Therapeutics

INDUSTRY