Zibotentan and Dapagliflozin in Patients With Type 2 Diabetes and Elevated Albuminuria

PHASE2CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

October 6, 2022

Primary Completion Date

March 5, 2025

Study Completion Date

March 5, 2025

Conditions
Chronic Kidney Diseases
Interventions
DRUG

Zibotentan

Zibotentan 1.5 mg once per day as a hard capsule.

DRUG

Dapagliflozin

Dapagliflozin 10 mg once per day as a tablet.

DRUG

Placebo

Matching placebo.

DRUG

Dapagliflozin and Zibotentan

Dapagliflozin 10 mg once per day as a tablet in combination with zibotentan 1.5 mg once per day as a hard capsule.

Trial Locations (7)

80045

Anschutz Medical Campus, Aurora

M5G 2N2

Toronto General Hospital, Toronto

H2W 1R7

Montreal Clinical Research Institute, Montreal

DK-2820

Steno Diabetes Center, Copenhagen

1081 HV

Amsterdam Universitair Academisch Centrum, Amsterdam

Unknown

University Medical Center Groningen, Groningen

EH16 4TJ

Center for Cardiovascular Science, Edinburgh

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

University Medical Center Groningen

OTHER