CD34+ Transplants for Leukemia and Lymphoma

Hyper-fractioned TBI is administered by a linear accelerator at a dose rate of \< 15 cGy/minute.

Thiotepa: 5 mg/kg/day IV over approximately 4 hours daily x 2 (Day -5 and Day -4).

Cyclophosphamide: 60 mg/kg/day x 2 or Fludarabine 25 mg/m\^2 x 5 if cyclophosphamide is contraindicated

Busulfan: 0.8 mg/kg every 6 hours x 10 or 12 doses (depending on disease) with dose modified according to pharmacokinetics

Melphalan: 70 mg/m\^2/day x 2

Fludarabine: 25 mg/m\^2/day x 5