NCT05562518View on ClinicalTrials.gov

GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.

PHASE4RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

March 21, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Vulvovaginal AtrophyBreast Cancer
Interventions
DRUG

Estrogen

1 vaginal ovule daily for three consecutive weeks, followed by 1 vaginal ovule 2 times per week

DRUG

dehydroepiandrosterone

1 vaginal ovule daily

DRUG

Estrogen + probiotics

1 vaginal ovule daily for 12 consecutive days, followed by 1 vaginal ovule 2 times per week

DRUG

Moisturizer

1 vaginal ovule daily for 14 consecutive days, followed by 1 vaginal ovule every three days

Trial Locations (1)

9000

RECRUITING

University Hospital Ghent, Ghent

All Listed Sponsors
collaborator

University Ghent

OTHER

lead

University Hospital, Ghent

OTHER