Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver Disease

PHASE1CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

August 12, 2022

Primary Completion Date

November 20, 2023

Study Completion Date

February 27, 2024

Conditions
Non-alcoholic Fatty Liver DiseaseFatty Liver, NonalcoholicNAFLDNonalcoholic Fatty Liver DiseaseNonalcoholic SteatohepatitisNASH
Interventions
DRUG

AZD7503 Intervention

"Part A: Participants will be screened for histologic evidence of NAFLD or NASH and all eligibility criteria in part A prior to enrollment in part B.~Part B: Participants consented to part B will be administered the study drug over the course of 31 days. At the end of the study a liver biopsy will be collected to measure for endpoints."

Trial Locations (1)

78215

Research Site, San Antonio

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY