Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis

NARecruitingINTERVENTIONAL
Enrollment

2,500

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Drug-resistant TuberculosisHIV CoinfectionCost-Benefit Analysis
Interventions
DIAGNOSTIC_TEST

Targeted next-generation sequencing

During intervention periods, an additional patient sample derived from routinely collected specimens will be processed by a local technician. Extracted DNA extracted from these samples will be batched on a regular basis for targeted deep sequencing. Sequencing results will be regularly transmitted to a clinical advisory committee.

Trial Locations (1)

Unknown

RECRUITING

South African National Health Laboratory Service, Cape Town

All Listed Sponsors
collaborator

University of Stellenbosch

OTHER

collaborator

National Health Laboratory Service (NHLS), South Africa

UNKNOWN

collaborator

National Institute for Communicable Diseases, South Africa

OTHER

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

Find

OTHER

collaborator

Translational Genomics Research Institute

OTHER

collaborator

University Hospital Heidelberg

OTHER

lead

University of California, San Francisco

OTHER