Phase II Trial of Consolidative Thoracic Radiotherapy for ES-SCLC After Standard Care of Chemo-immunotherapy

NARecruitingINTERVENTIONAL
Enrollment

104

Participants

Timeline

Start Date

January 30, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2026

Conditions
Small-cell Lung Cancer
Interventions
RADIATION

thoracic radiotherapy

Four courses of carboplatin/etoposide/anti-PD-1/PD-L1 every 3 weeks All the enrolled patients will be patients with ES-SCLC who did not have PD (determined as per the RECIST v1.1) after 6 cycle of platinum-based chemotherapy in combination with an anti-PD-1/L1. Then, thoracic radiotherapy of 45 Gy/15 fractions. PD-1/PD-L1 maintenance therapy concurrently and after thoracic radiotherapy at least more than 6 months, or until intolerable toxicity, progressive disease leading to a need for other treatment, or until the patient no longer wishes to continue treatment.

Trial Locations (1)

200025

RECRUITING

Ruijin Hospital, Shanghai jiaotong univestigy school of medicine, Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER