Study of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants With Both Chronic Hepatitis B and HIV

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

May 5, 2023

Primary Completion Date

November 15, 2025

Study Completion Date

April 29, 2026

Conditions
Hepatitis BHIV Infections
Interventions
DRUG

Selgantolimod

1.5 mg tablet

DRUG

Placebo

Matching placebo tablet

Trial Locations (30)

1862

Soweto ACTG CRS, Johannesburg

4091

Durban International CRS, Durban

4114

De La Salle Health Science Institute Angelo King Medical Research Center (DLSHSI-AKMRC), Cavite

10011

Weill Cornell Chelsea CRS, New York

10065

Weill Cornell Uptown CRS, New York

10330

Thai Red Cross AIDS Research Centre (TRC-ARC) CRS, Pathum Wan

15213

Univ of Pittsburgh, Pittsburgh

20005

Whitman-Walker Health CRS, Washington D.C.

27401

Greensboro CRS Site# 3203, Greensboro

27599

Chapel Hill CRS, Chapel Hill

30308

The Ponce de Leon Center CRS, Atlanta

35222

Alabama CRS, Birmingham

37204

Vanderbilt Therapeutics (VT) CRS, Nashville

43210

Ohio State University CRS, Columbus

44106

Case CRS Site ID# 2501, Cleveland

50200

Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai

60611

Northwestern University CRS, Chicago

77030

Houston AIDS Research Team CRS, Houston

92103

UCSD Antiviral Research Center CRS, San Diego

452292899

Cincinnati Children's Hosp / Univ Hosp, Cincinnati

07103

New Jersey Medical School Clinical Research Center CRS, Newark

10032-3732

Columbia P&S CRS, New York

98104-9929

University of Washington AIDS CRS, Seattle

91350-200

Hospital Nossa Senhora da Conceicao CRS, Porto Alegre

21040-360

Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS Site ID# 12101, Rio de Janeiro

Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro

HT-6110

GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS, Port-au-Prince

04

Barranco CRS, Lima

Unknown

Joint Clinical Research Centre (JCRC)/Kampala Clinical Research Site, Kampala

Milton Park CRS, Milton Park

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH