Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15

PHASE2CompletedINTERVENTIONAL
Enrollment

187

Participants

Timeline

Start Date

November 21, 2022

Primary Completion Date

March 13, 2024

Study Completion Date

April 23, 2025

Conditions
Non-small Cell Lung CancerPancreatic CancerColorectal CancerLoss of AppetiteFatigueCachexia
Interventions
DRUG

ponsegromab

Double-Blind ponsegromab Treatment followed by Open Label ponsegromab Treatment

DRUG

Placebo for ponsegromab

Double-Blind placebo Treatment followed by Open Label ponsegromab Treatment

Trial Locations (78)

333

Chang Gung Medical Foundation-Linkou Branch, Taoyuan District

704

National Cheng Kung University Hospital, Tainan City

1083

Semmelweis Egyetem, Budapest

1121

Országos Korányi Pulmonológiai Intézet, Budapest

1303

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia

1330

MHAT for Women's Health Nadezhda, Sofia

1797

University Multiprofile Hospital for Active Treatment Sofiamed, Sofia

2010

St Vincent's Hospital Sydney, Darlinghurst

2800

Orange Hospital, Orange

3000

Peter MacCallum Cancer Centre, Melbourne

Complex Oncology Center - Vratsa, Vratsa

3021

Western Health-Sunshine & Footscray Hospitals, St Albans

5004

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház, Szolnok

6000

Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét

6300

Specialized Hospital for Active Treatment of Oncology - Haskovo, Haskovo

7002

Complex Oncology Center - Ruse EOOD, Rousse

8000

Complex Oncology Center - Burgas, Burgas

9700

Complex Oncology Center - Shumen, Shumen

28050

Hospital Universitario HM Sanchinarro, Madrid

46009

Fundación Instituto Valenciano de Oncología, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

47904

IU Health Arnett Cancer Center, Lafayette

59715

Bozeman Health Deaconess Hospital, Bozeman

70072

Tandem Clinical Research, Marrero

70808

Pennington Biomedical Research Center, Baton Rouge

72034

CARTI Conway, Conway

72117

CARTI North Little Rock, North Little Rock

72160

CARTI Stuttgart, Stuttgart

72205

CARTI Cancer Center, Little Rock

73657

Chi Mei Hospital - Liouying Branch, Tainan City

77030

The University of Texas MD Anderson Cancer Center, Houston

78212

Carta - Clinical Associates in Research Therapeutics of America, LLC, San Antonio

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

90211

Beverly Hills Cancer Center, Beverly Hills

92373

Emad Ibrahim,MD,INC., Redlands

92801

Pacific Cancer Medical Center INC, Anaheim

95403

Providence Medical Foundation, Santa Rosa

95801

Nemocnica na okraji mesta, n.o., Partizánske

97239

Oregon Health and Science University: Center for Health and Healing 1, Portland

Oregon Health and Science University: Center for Health and Healing 2, Portland

Oregon Health and Science University, Portland

98101

Virginia Mason Medical Center, Seattle

98801

Wenatchee Valley Hospital, Wenatchee

100034

Peking University First Hospital, Beijing

200433

Shanghai Changhai Hospital, Shanghai

213003

Changzhou No.2 People's Hospital, Changzhou

250012

Qilu Hospital of Shandong University, Jinan

310016

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

325035

The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

404332

China Medical University Hospital, Taichung

430030

Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

G7H 5H6

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi

G5L 5T1

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski

030013

Shanxi Provincial Cancer Hospital, Taiyuan

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

673-8558

Hyogo Cancer Center, Akashi

241-8515

Kanagawa cancer center, Yokohama

464-8681

Aichi Cancer Center Hospital, Nagoya

411-8777

Shizuoka Cancer Center, Nagaizumi-cho

602-8566

University Hospital,Kyoto Prefectural University of Medicine, Kyoto

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

30-348

Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o., Krakow

86-300

Regionalny Szpital Specjalistyczny im. Dr. Wladyslawa Bieganskiego, Grudziądz

40-060

"NZOZ Vegamed", Katowice

20-093

Specjalistyczna Praktyka Lekarska Slawomir Mandziuk, Lublin

975 17

Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica, Banská Bystrica

826 06

Univerzitna nemocnica Bratislava, Nemocnica Ruzinov, Bratislava

833 10

Narodny onkologicky ustav, II. Onkologicka klinika LFUK a NOU, Bratislava

940 34

Fakultna nemocnica s poliklinikou Nove Zamky, Nové Zámky

917 75

Fakultna nemocnica Trnava, Trnava

08915

Hospital Universitari General de Catalunya, Sant Cugat del Vallès

08908

Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet de Llobregat

07198

Hospital Son Llàtzer, Palma

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT05546476 - Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 | Biotech Hunter | Biotech Hunter