Study of Oral MRT-2359 in Selected Cancer Patients

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

October 12, 2022

Primary Completion Date

May 31, 2026

Study Completion Date

November 30, 2027

Conditions
NSCLCSCLCHigh Grade Neuroendocrine CancerDLBCLL-MYC and N-MYC Amplified Solid TumorsNSCLC With High or Low L-MYC or N-MYC ExpressionHR-positive, HER2-negative Breast CancerProstate Cancer
Interventions
DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359.

DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359.

DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359.

DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359.

DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359 in conjunction with intramuscular administration of fulvestrant.

DRUG

Oral MRT-2359

Orally administered tablets of MRT-2359 in conjunction with orally administered enzalutamide.

Trial Locations (22)

10021

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10032

RECRUITING

Columbia University Irving Medical Centre, New York

22031

RECRUITING

Virginia Cancer Specialists Research Institute, Fairfax

32746

RECRUITING

Sarah Cannon Research Institute, Lake Mary

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

46202

WITHDRAWN

Indiana University, Bloomington

48202

RECRUITING

Henry Ford Cancer Institute, Detroit

49546

RECRUITING

South Texas Accelerated Research Therapeutics (START) Midwest, Grand Rapids

63110

ACTIVE_NOT_RECRUITING

Washington University, St Louis

66044

RECRUITING

University of Kansas Cancer Center, Lawrence

75251

RECRUITING

Mary Crowley Cancer Research, Dallas

78229

RECRUITING

South Texas Accelerated Research Therapeutics (START), San Antonio

84119

RECRUITING

South Texas Accelerated Research Therapeutics (START) Mountain Region, West Valley City

85258

RECRUITING

Honor Health Research Institute, Scottsdale

92037

RECRUITING

University of California San Diego, San Diego

92663

RECRUITING

Hoag Memorial Hospital Presbyterian, Newport Beach

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

06520

ACTIVE_NOT_RECRUITING

Yale University, New Haven

02215

ACTIVE_NOT_RECRUITING

Dana Farber Cancer Institute, Boston

77030-4009

RECRUITING

MD Anderson Cancer Center, Houston

T6G 1Z2

ACTIVE_NOT_RECRUITING

Cross Cancer Institute, Edmonton

M5G 2C4

ACTIVE_NOT_RECRUITING

Princess Margaret Hospital, Toronto

Sponsors
All Listed Sponsors
lead

Monte Rosa Therapeutics, Inc

INDUSTRY

NCT05546268 - Study of Oral MRT-2359 in Selected Cancer Patients | Biotech Hunter | Biotech Hunter