Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

November 22, 2022

Primary Completion Date

November 30, 2026

Study Completion Date

June 30, 2027

Conditions
Locally Advanced Urothelial CarcinomaMetastatic Urothelial CarcinomaSolid TumorUrothelial CarcinomaSolid Tumor, AdultBladder CancerNon-muscle-invasive Bladder CancerFGFR3 Gene MutationFGFR3 Gene AlterationAdvanced Solid TumorAdvanced Urothelial CarcinomaUrinary Tract CancerUrinary Tract TumorUrinary Tract Carcinoma
Interventions
DRUG

TYRA-300

TYRA-300 is an oral, novel potent FGFR 3-selective tyrosine kinase inhibitor that targets tumors that contain activating gene alterations of FGFR3.

Trial Locations (21)

2109

RECRUITING

Macquarie University, Macquarie Park

3000

RECRUITING

Peter MacCallum Cancer Research Unit, Melbourne

3084

RECRUITING

Austin Health, Heidelberg

4102

RECRUITING

Princess Alexandra Hospital, Woolloongabba

4215

RECRUITING

Tasman Oncology, Southport

6009

RECRUITING

Linear Clinical Research Limited, Nedlands

10021

RECRUITING

Memorial Sloan Kettering Cancer Center (MSKCC), New York

27710

RECRUITING

Duke Cancer Institute (DCI) - Duke Cancer Center, Durham

28223

RECRUITING

NEXT Madrid - Hospital Universitario Quironsalud Madrid, Madrid

29605

WITHDRAWN

Prisma Health Cancer Institute - Faris, Greenville

31059

RECRUITING

Institut Claudius Regaud, IUCT-Oncopole, Toulouse

34474

WITHDRAWN

Florida Cancer Affiliates - Ocala - Main (Ocala Oncology - Ocala), Ocala

37232

RECRUITING

Vanderbilt University Medical Center (VUMC) - Vanderbilt-Ingram Cancer Center (VICC) - Nashville, Nashville

44195

RECRUITING

Cleveland Clinic - Main Campus, Cleveland

44805

RECRUITING

Institut de Cancerologie de L'Ouest (ICO), Saint-Herblain

94805

RECRUITING

Gustave Roussy (Institut de Cancerologie Gustave-Roussy), Villejuif

98109

RECRUITING

Seattle Cancer Care Alliance (SCCA) - South Lake Union, Seattle

02215

RECRUITING

Dana Farber Cancer Institute, Boston

01655

RECRUITING

UMass Memorial Medical Center, Worcester

08023

RECRUITING

NEXT Barcelona - Hospital Quironsalud Barcelona, Barcelona

08035

RECRUITING

Vall d'Hebron Institut d'Oncologia (VHIO), Barcelona

All Listed Sponsors
lead

Tyra Biosciences, Inc

INDUSTRY