Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)

NAActive, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

December 28, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Complete Heart BlockHigh Degree Second Degree Atrioventricular BlockPacemaker-Induced CardiomyopathyAortic Valve Stenosis
Interventions
DEVICE

Right ventricular septal pacing followed by left bundle branch area pacing

All patients will undergo implantation of right ventricular septal lead, left bundle branch area lead, and atrial lead in the absence of permanent atrial fibrillation with a CRT-pacing generator. Patients will be randomized to pacing protocols based on group assignment and crossover during the study.

DEVICE

Left bundle branch area pacing followed by right ventricular septal pacing

All patients will undergo implantation of right ventricular septal lead, left bundle branch area lead, and atrial lead in the absence of permanent atrial fibrillation with a CRT-pacing generator. Patients will be randomized to pacing protocols based on group assignment and crossover during the study.

Trial Locations (4)

19096

Lankenau Medical Center, Wynnewood

19104

Hospital of the University of Pennsylvania, Philadelphia

66211

Kansas City Heart Rhythm Institute, Overland Park

07450

Valley Health System, Ridgewood

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Sharpe-Strumia Research Foundation

OTHER

collaborator

Medtronic

INDUSTRY

lead

Main Line Health

OTHER