A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

October 11, 2022

Primary Completion Date

July 7, 2026

Study Completion Date

May 4, 2027

Conditions
Advanced Solid Tumors
Interventions
DRUG

BAY3375968

Intravenous (IV) infusion

DRUG

Pembrolizumab

IV infusion

Trial Locations (26)

4000

CHU de Liège, Liège

27514

UNC Hospitals - UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28027

Clinica Universidad de Navarra-Oncology Service, Madrid

28050

The START Center for Cancer Care - Madrid - CIOCC - Hospital Universitario Madrid Sanchinarro - Oncologia, Madrid

31008

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona, Pamplona

33000

Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale, Bordeaux

44800

Institut de Cancerologie Ouest - Saint Herblain - Oncologie medicale, Saint-Herblain

59000

Centre Oscar Lambret - Service Oncologie, Lille

60637

The University of Chicago Medical Center - Hyde Park - Hematology & Oncology, Chicago

94805

Institut Gustave Roussy - Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP), Villejuif

119074

National University Hospital Medical Centre, Singapore

130000

Jilin Cancer Hospital, Changchun

168583

National Cancer Center Singapore - Oncology Department, Singapore

276001

LinYi Cancer Hospital (Linyi Tumor Hospital), Linyi

510000

Guangdong Provincial People's Hospital, Guangzhou

510655

The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou

Texas

"START , San Antonio"

Utah

"South Texas Accelerated Research Therapeutics , START Rocky Mountain Region"

Unknown

"Antwerp University Hospital , Oncology Department"

"Ghent University Hospital , Drug Research Unit Department"

"Universitair Ziekenhuis Leuven , Gasthuisberg Campus - General Medical Oncology"

"OncoCare Cancer Centre , Gleneagles Medical Centre"

M5G 2C4

Princess Margaret Cancer Centre - Oncology Department, Toronto

08035

Hospital Universitari Vall d'Hebron- Oncology Service, Barcelona

SM2 5PT

Royal Marsden NHS Trust (Surrey), Sutton

M204BX

The Christie NHS Foundation Trust - Christie Hospital, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY