Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)

"(1) Modified FOLFIRINOX (mFOLFIRINOX) regimen: 6 cycles every 2 weeks~* Oxaliplatin 85mg/m2 IV infusion over 120 min D1~* Leucovorin 400mg/m2 IV (concurrently with oxaliplatin)~* Irinotecan 150mg/m2 IV infusion over 60-90 min D1~* 5-fluorouracil 2,400mg/m2 IV infusion continuously over 46-48h D1-2"

"1. FOLFOX regimen: 6 cycles every 2 weeks~ * Oxaliplatin 85mg/m2 IV infusion over 120 min D1~ * Leucovorin 400mg/m2 IV infusion over 120 min (concurrently with oxaliplatin)~ * 5-fluorouracil 400mg/m2 IV bolus D1~ * 5-fluorouracil 2,400mg/m2 IV infusion continuously over 46-48h D1-2 or~2. CAPOX regimen: 4 cycles every 3 weeks~ * Oxaliplatin 130mg/m2 IV infusion over 120 min D1~ * Capecitabine 1,000mg/m2 PO bid D1-14"