Nocardia Rubra Cell Wall Skeleton (N-CWS) Plus HAIC, Lenvatinib and Tislelizumab in Treating Patients With Advanced HCC

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

August 31, 2024

Study Completion Date

February 28, 2025

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Nocardia rubra cell wall skeleton

Nocardia rubra cell wall skeleton (N-CWS) 400μg hypodermic injected every 1 week (Q1W) for 4 weeks, following by N-CWS 400μg hypodermic injected every 4 weeks (Q4W)

PROCEDURE

Hepatic arterial infusion chemotherapy

administration of oxaliplatin , fluorouracil, and leucovorin via the tumor feeding arteries every 3 weeks

DRUG

Lenvatinib

12 mg (or 8 mg) once daily (QD) oral dosing

DRUG

Tislelizumab

200mg intravenously every 3 weeks

Trial Locations (1)

430030

RECRUITING

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
collaborator

Chinese Cooperative Group of Liver Cancer

OTHER

collaborator

Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province

OTHER

collaborator

M&R Pharm

UNKNOWN

collaborator

Geneplus-Beijing Co. Ltd.

INDUSTRY

collaborator

Yuce Biotechnology Co., Ltd.

UNKNOWN

collaborator

Geneis

UNKNOWN

collaborator

Simcere Pharmaceutical Co., Ltd

OTHER

collaborator

BeiGene

INDUSTRY

collaborator

Haplox Biotechnology Co., Ltd.

INDUSTRY

lead

Wan-Guang Zhang

OTHER

NCT05533892 - Nocardia Rubra Cell Wall Skeleton (N-CWS) Plus HAIC, Lenvatinib and Tislelizumab in Treating Patients With Advanced HCC | Biotech Hunter | Biotech Hunter