De-escalation Study for Stage IIa/IIb < 3 cm Seminoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

September 6, 2022

Primary Completion Date

September 6, 2025

Study Completion Date

September 6, 2030

Conditions
SeminomaStage II
Interventions
RADIATION

Radiotherapy boost

"Radiotherapy boost 20 to 30 Gy, in daily 2 Gy fractions and 5 fractions per week :~* 20 Gy if no more disease is visible (node \< 1 cm in large diameter)~* 24 Gy for nodes \<= 2 cm~* 30 Gy for nodes \> 2 cm"

DRUG

Carboplatin AUC7

Carboplatin at dose (mg) = AUC7 (mg/ml x min) x (DFG ml/min + 25)

DRUG

3 cycles of EP

3 Cycles of EP chemotherapy, administred every 3 weeks following standard practice

Trial Locations (15)

Unknown

NOT_YET_RECRUITING

CHU Besançon, Besançon

RECRUITING

CHU Bordeaux, Bordeaux

RECRUITING

Centre François Baclesse, Caen

RECRUITING

Centre Jean Perrin, Clermont-Ferrand

RECRUITING

Centre Oscar Lambret, Lille

RECRUITING

CHU de Limoges, Limoges

RECRUITING

Centre Leon Bérard, Lyon

RECRUITING

Institut Paoli Calmettes, Marseille

RECRUITING

Centre Antoine Lacassagne, Nice

NOT_YET_RECRUITING

Hôpital Saint Louis, Paris

RECRUITING

ICO René Gauducheau, Saint-Herblain

NOT_YET_RECRUITING

Hôpital Foch, Suresnes

RECRUITING

Institut Universitaire de Cancer de Toulouse (IUCT-O), Toulouse

NOT_YET_RECRUITING

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

RECRUITING

Institut Gustave Roussy, Villejuif

All Listed Sponsors
lead

Centre Leon Berard

OTHER