Norepinephrine for Prevention of Intraoperative Hypotension in Infants Undergoing Kasai Portoenterostomy

PHASE3CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

August 28, 2022

Primary Completion Date

July 8, 2024

Study Completion Date

July 8, 2024

Conditions
AnesthesiaPediatricsBiliary Atresia
Interventions
DRUG

Norepinephrine Bitartrate

"anesthesia resident (who will not be involved in patient management to ensure the blinding) will be responsible for preparing norepinephrine infusion or placebo as instructed in the envelope as follow: 1 mg norepinephrine will be diluted in dextrose 5% in a 50 mL syringe using a nomogram based on the infant body weight so that 1mL= 0.05 µg/kg/min norepinephrine infusion.~the attending anesthetist will be instructed to set the 2 syringe pumps on 2 mL/h continuous infusion following skin incision."

DRUG

Placebo

Placebo

Trial Locations (1)

11559

Cairo university hospitals, Cairo

All Listed Sponsors
lead

Kasr El Aini Hospital

OTHER