Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors

PHASE2RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2026

Conditions
ImmunotherapyGastric CancerRectal CancerChemotherapy EffectRadiotherapy
Interventions
DRUG

Terelizumab (aka Tislelizumab)

q3w Terelizumab (aka Tislelizumab) 200mg on day 1 of each cycle

DRUG

CapeOx

Oxaliplatin(130mg/m2) on day 1 of each cycle and Capecitabine:Dose of 1000mg/m2,14days

DRUG

Trastuzumab

q3w Trastuzumab (6 mg/kg following an initial loading dose of 8 mg/kg) on day 1 of each cycle

RADIATION

Radiotherapy

25 Gy/5 fractions

Trial Locations (1)

400000

RECRUITING

Army Medical Center, Chongqing

All Listed Sponsors
lead

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

OTHER