Overcoming Nicotine Dependence to Enable Quitting

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

780

Participants

Timeline

Start Date

March 24, 2023

Primary Completion Date

August 30, 2027

Study Completion Date

August 30, 2027

Conditions
Tobacco UseSmoking CessationSmoking BehaviorsNicotine DependenceNicotine Withdrawal
Interventions
DRUG

Nicotine Replacement Therapy (NRT) Sampling

Participants randomized to this condition will receive a 4-week nicotine replacement therapy (NRT) starter kit containing both nicotine lozenges and patches in their original packaging.

BEHAVIORAL

Practice Quitting (PQ) Counseling

Practice Quitting (PQ) counseling will consist of four weekly treatment sessions, with an initial 45-minute session followed by three 20-minute sessions. The goals of the counseling sessions are 1) to gradually expose patients to nicotine withdrawal symptoms through practice quitting, and 2) to reduce fear and avoidance of the physical sensations associated with nicotine withdrawal.

BEHAVIORAL

Motivational Interviewing (MI) Counseling

Motivational Interviewing (MI) counseling will consist of four weekly treatment sessions, with an initial 45-minute session followed by three 20-minute sessions. Counseling content will incorporate MI-consistent principles, such as open questions, simple and complex reflections, and affirmations to facilitate participant statements in favor of behavior change. Discussion will focus on the motivational topics outlined in the USPHS guidelines for smokers not ready to quit: 1) relevance of smoking cessation or reduction to the individual, 2) risks of continued heavy smoking, 3) rewards of quitting and reduction, and 4) roadblocks to success, on a 5) repeated basis.

Trial Locations (1)

60612

RECRUITING

Rush University Medical Center, Chicago

All Listed Sponsors
collaborator

Medical University of South Carolina

OTHER

lead

Rush University Medical Center

OTHER