Nituzumab (Taixinsheng ®) A Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Clinical Study on the Efficacy and Safety of Combined Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinomatreatment of Locally Advanced Nasopharyngeal Carcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

April 20, 2022

Primary Completion Date

October 30, 2025

Study Completion Date

October 30, 2027

Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG

Nituzumab/placebo

"Test group: 3 cycles of induction chemotherapy combined with 9 times of nituzumab targeted therapy followed by 2-3 cycles of synchronous radiotherapy and chemotherapy combined with 7 times of nituzumab targeted therapy, a total of 16 times of nituzumab targeted therapy, equivalent to the whole course targeted therapy.~Control group: 3 cycles of induction chemotherapy combined with 9 times of placebo treatment followed by 2-3 cycles of concurrent chemoradiotherapy combined with 7 times of nituzumab targeted therapy, a total of 7 times of nituzumab targeted therapy, only targeted therapy during concurrent chemoradiotherapy"

Trial Locations (1)

610041

RECRUITING

Sichuan Cancer Hospital, Chengdu

All Listed Sponsors
lead

Sichuan Cancer Hospital and Research Institute

OTHER