A Clinical Study of Hanlikang and BTK Inhibitors in the Treatment of Newly Diagnosed Mantle Cell Lymphoma

RecruitingOBSERVATIONAL
Enrollment

100

Participants

Timeline

Start Date

August 12, 2022

Primary Completion Date

June 30, 2024

Study Completion Date

December 30, 2026

Conditions
Newly Diagnosed Mantle Cell Lymphoma
Interventions
DRUG

Rituximab

Young patients (\< 65 years of age) were treated with R-BAP for 6 cycles (efficacy was assessed every 2 cycles, and adverse events were recorded), together with oral ibrutinib, followed by oral ibrutinib for 1 year after chemotherapy (efficacy was assessed every 3 months). Elderly patients (≥65 years of age) received 4 cycles of R-BAP (efficacy assessed every 2 cycles, and adverse reactions recorded), followed by 4 cycles of rituximab consolidation (efficacy assessed every 2 cycles) and 1 year of oral zanubrutinib (efficacy assessed every 3 months).

Trial Locations (1)

450000

RECRUITING

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou

All Listed Sponsors
lead

Zhengzhou University

OTHER