Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

November 7, 2022

Primary Completion Date

November 20, 2024

Study Completion Date

December 31, 2026

Conditions
Breast Cancer
Interventions
DRUG

Neoadjuvant Olaparib monotherapy group

Neoadjuvant olaparib monotherapy (300 mg BID) for four to six 28-day cycles.

COMBINATION_PRODUCT

Neoadjuvant combination therapy with olaparib plus durvalumab

Neoadjuvant combination therapy with olaparib (300 mg BID) plus durvalumab (1500 mg IV Q4W) for four to six 28-day cycles.

Trial Locations (37)

1200

Research Site, Brussels

3000

Research Site, Melbourne

4000

Research Site, Liège

5020

Research Site, Salzburg

6830

Research Site, Rankweil

8035

Research Site, Barcelona

10003

Research Site, Cáceres

15006

Research Site, A Coruña

19104

Research Site, Philadelphia

20246

Research Site, Hamburg

25198

Research Site, Lleida

28041

Research Site, Madrid

29010

Research Site, Málaga

30625

Research Site, Hanover

40138

Research Site, Bologna

41009

Research Site, Seville

41013

Research Site, Seville

41124

Research Site, Modena

44218

Research Site, Kfar Saba

45130

Research Site, Essen

46010

Research Site, Valencia

47014

Research Site, Meldola

50931

Research Site, Cologne

69120

Research Site, Heidelberg

76100

Research Site, Rehovot

80537

Research Site, Loveland

80631

Research Site, Greeley

81377

Research Site, München

86156

Research Site, Augsburg, by

91120

Research Site, Jerusalem

97239

Research Site, Portland

5262000

Research Site, Ramat Gan

02215

Research Site, Boston

00168

Research Site, Roma

08036

Research Site, Barcelona

08907

Research Site, Hospitalet deLlobregat

NG5 1PB

Research Site, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY