Nivolumab-ipilimumab and Chemoradiation for Cervical Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

August 30, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

March 31, 2028

Conditions
Uterine Cervical Neoplasms
Interventions
DRUG

Nivolumab 40 mg in 4 ml Injection

Nivolumab 1mg/kg every 3 weeks for 4 cycles prior to radiation and 240mg every 2 weeks with concurrent radiation

DRUG

Ipilimumab 200 MG in 40 ML Injection

Ipilimumab 3mg/kg every 3 weeks for 4 cycles prior to radiation

RADIATION

Chemoradiation

Radiation to a dose of 45Gy over 25 1.8Gyfractions and brachytherapy with concurrent weekly cisplatin 40mg/m2/w or carboplatin AUC 2/w

Trial Locations (14)

60335-480

RECRUITING

CRIO -Centro Regional Integrado de Oncologia, Fortaleza

41810-011

RECRUITING

Clinica AMO, Salvador

30130-100

NOT_YET_RECRUITING

Hospital das Clinicas da UFMG, Belo Horizonte

81520-060

NOT_YET_RECRUITING

Hospital Erasto Gaertner, Curitiba

50070-460

RECRUITING

Multi Oncoclinicas Recife, Recife

90610-001

NOT_YET_RECRUITING

Hospital São Lucas - PUCRS, Porto Alegre

69310-000

RECRUITING

Universidade Federal de Roraima, Boa Vista

88034-000

NOT_YET_RECRUITING

CEPON - Florianópolis, Florianópolis

14784-400

NOT_YET_RECRUITING

Hospital de Amor, Barretos

15090-000

NOT_YET_RECRUITING

Hospital De Base de São José do Rio Preto - CIP São José, São José do Rio Preto

20230-130

NOT_YET_RECRUITING

INCA - Instituto Nacional do Cancer, Rio de Janeiro

01509-001

NOT_YET_RECRUITING

AC Camargo Cancer Center, São Paulo

04378-500

RECRUITING

Hospital Municipal Vila Santa Catarina, São Paulo

05652-900

RECRUITING

Hospital Israelita Albert Einstein, São Paulo

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Brava

INDUSTRY

lead

Hospital Israelita Albert Einstein

OTHER

NCT05492123 - Nivolumab-ipilimumab and Chemoradiation for Cervical Cancer | Biotech Hunter | Biotech Hunter