Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

August 1, 2022

Primary Completion Date

August 31, 2024

Study Completion Date

December 31, 2026

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Ensartinib

Participants will receive Ensartinib 225 mg oral once daily from baseline until disease progression, unacceptable toxicity, withdrawal of consent or death.

DRUG

Bevacizumab

Participants will receive 7.5 mg/kg intravenous on Day 1 of 21 day cycles (every 3 weeks) from baseline until disease progression, unacceptable toxicity, withdrawal of consent or death.

Trial Locations (1)

Unknown

Sun Yat-Sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

collaborator

Shenyang Chest Hospital

OTHER

collaborator

Hebei Medical University Fourth Hospital

OTHER

collaborator

First People's Hospital of Foshan

OTHER

collaborator

Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Guangzhou Institute of Respiratory Disease

OTHER

collaborator

Central People's Hospital of Zhanjiang

OTHER

collaborator

Guangdong Provincial Agricultural Reclamation Central Hospital

UNKNOWN

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

West China Hospital

OTHER

collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

collaborator

Yuebei People's Hospital

OTHER

collaborator

Yunnan Cancer Hospital

OTHER

lead

Sun Yat-sen University

OTHER