Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis

PHASE4RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Hemophagocytic LymphohistiocytosesCytokine Storm
Interventions
DRUG

Dexamethasone

Single drug in non-severe group; combined with etoposide±ruxolitinib in severe group.

DRUG

Etoposide

Used in severe group combined with etoposide.

DRUG

Ruxolitinib

Single drug in non-severe group; combined with etoposide and dexamethasone in severe group.

Trial Locations (1)

310003

RECRUITING

The Children's Hospital of Zhejiang University School of Medicine, Hangzhou

All Listed Sponsors
collaborator

The Second Hospital of Anhui Medical University

OTHER

collaborator

Union hospital of Fujian Medical University

OTHER

collaborator

Children's Hospital of Fudan University

OTHER

collaborator

Zunyi Medical College

OTHER

collaborator

Hunan Provincial People's Hospital

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

Children's Hospital of Nanjing Medical University

OTHER

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Shanghai Children's Medical Center

OTHER

collaborator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

Shanghai Children's Hospital

OTHER

collaborator

Shenzhen Children's Hospital

OTHER_GOV

collaborator

West China Second University Hospital

OTHER

collaborator

Children's Hospital of Soochow University

OTHER

collaborator

Second Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Wuhan Children's Hospital

OTHER

collaborator

Institute of Hematology & Blood Diseases Hospital, China

OTHER

collaborator

The Third Xiangya Hospital of Central South University

OTHER

collaborator

First Affiliated Hospital, Sun Yat-Sen University

OTHER

lead

The Children's Hospital of Zhejiang University School of Medicine

OTHER

NCT05491304 - Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis | Biotech Hunter | Biotech Hunter