NCT05489575View on ClinicalTrials.gov

CPAP for the Treatment of Supine Hypertension

NARecruitingINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

June 23, 2022

Primary Completion Date

March 1, 2026

Study Completion Date

August 31, 2026

Conditions
Autonomic FailurePure Autonomic FailureMultiple System AtrophyParkinson DiseaseSupine HypertensionNeurogenic Orthostatic Hypotension
Interventions
DEVICE

Active CPAP

Continuous positive airway pressure (CPAP) is applied at 8, 10, or 12 cm H20. The active CPAP level will be determined during a CPAP titration trial

DEVICE

Sham CPAP

Sham continuous positive airway pressure applied at \<4 cm H2O

OTHER

Sleeping in a head-up tilt (HUT) position

Sleeping with the whole bed tilted head-up by 10 degrees or with the head elevated by 13-14 inches.

Trial Locations (1)

37232

RECRUITING

Autonomic Dysfunction Center/ Vanderbilt University Medical Center, Nashville

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Vanderbilt University Medical Center

OTHER