A Clinical Study of Disitamab Vedotin for Injection Combined With Penpulimab Injection in Neoadjuvant Therapy for Patients With HER2-expressing Cisplatin-intolerant cT2-T4aNxM0 Bladder Urothelial Carcinoma

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
Bladder Cancer
Interventions
DRUG

Disitamab Vedotin for Injection,Penpulimab Injection

"After completion of all screening activities, patients confirmed to be eligible will enter the study and receive the following treatments.~Neoadjuvant regimen (up to 4 cycles): Disitamab Vedotin for Injection, 2.0 mg/kg, given as an IV infusion on day 1, and Penpulimab Injection, 200 mg, on every 21 days On day 1 of the cycle, it is given as an intravenous infusion. Order of use: Disitamab Vedotin for Injection → Penpulimab Injection."

All Listed Sponsors
collaborator

Third Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Nanfang Hospital, Southern Medical University

OTHER

collaborator

Southern Medical University, China

OTHER

collaborator

The Third Affiliated Hospital of Southern Medical University

OTHER_GOV

lead

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER