SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation

PHASE1TerminatedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

July 6, 2022

Primary Completion Date

August 22, 2024

Study Completion Date

August 22, 2024

Conditions
Solid Tumor, AdultMetastatic Solid TumorMetastatic NSCLCNon Small Cell Lung Cancer
Interventions
DRUG

BBP-398

BBP-398 administered orally

DRUG

sotorasib

sotorasib administered orally

Trial Locations (25)

3199

Peninsula & South Eastern Haematology and Oncology Group, Frankston

5000

Cancer Research SA, Adelaide

5042

Southern Oncology Clinical Research Unit, Adelaide

6008

St John of God Subiaco Hospital, Subiaco

6009

One Clinical Research, Perth

21079

Centre Georges François Leclerc, Dijon

25123

Spedali Civili - Brescia, Brescia

28027

Clinica Universidad de Navarra, Madrid

28223

Quiron Salud Madrid, Madrid

29010

Virgen De La Victoria, Málaga

33076

Institute Bergonie, Bordeaux

35000

CHU de Rennes - Hôpital Pontchaillou, Rennes

50134

Careggi University Hospital, Florence

55236

St. Luke's Hospital S.A., Thessaloniki

75018

Hopital Bichat-Claude Bernard, Paris

80131

"Istituto Nazionale Tumori (INT) Fondazione G. Pascale", Napoli

"U.O.C Oncoematologia AOU Luigi Vanvitelli", Napoli

NSW 2800

Orange Health Service, Orange

DK-2100

Rigshospitalet, Copenhagen

38043 CEDEX9

CHU Grenobles Aples, Grenoble

1066 CX

Het Nederlands Kanker Instituut - Antoni van Leewenhoek Ziekenhuis, Amsterdam

3000 CA

Erasmus Medical Center, Rotterdam

08023

Quiron Salud Barcelona, Barcelona

08035

Vall d'Heborn University Hospital - VHIO, Barcelona

Unknown

Hospital Universitario Virgen De La Macarena, Seville

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

lead

Navire Pharma Inc., a BridgeBio company

INDUSTRY

NCT05480865 - SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation | Biotech Hunter | Biotech Hunter