Trial to Evaluate the Safety and Immunogenicity of Priming Regimens of 426c.Mod.Core-C4b and Optional Boost Regimen With HIV Trimer BG505 SOSIP.GT1.1 gp140, Both Adjuvanted With 3M-052-AF + Alum in Healthy, Adult Participants Without HIV

Administered via injection as a split dose into the deltoid muscle (both left and right).

Administered via injection as a split dose into the deltoid muscle (both left and right).

Administered via injection as a split dose into the deltoid muscle (both left and right).

Administered via injection as a split dose into the deltoid muscle (both left and right).

A soluble, cleavage-competent, trimeric HIV-1 envelope glycoprotein gp140 formulated at 2 mg/mL, 0.55 mL per vial, in 20 mM Tris, 100 mM NaCl, pH 7.5 will be admixed with 3M-052-AF (5 mcg) + Alum (500 mcg