Crizanlizumab Improves Tissue Oxygen Supply Demand Matching in Patients With Sickle Cell Anemia

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 1, 2024

Primary Completion Date

July 1, 2028

Study Completion Date

July 1, 2029

Conditions
Sickle Cell Disease
Interventions
DRUG

Crizanlizumab

patients will be started on 5mg/kg of body weight to be initiated at week 1 with follow up dosing at week 3 and week 7 then q4weeks until week 23, which will be the last dose given (7 total doses).

OTHER

control

Standard of care

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Children's Hospital Los Angeles

OTHER