A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

March 6, 2023

Primary Completion Date

January 31, 2025

Study Completion Date

April 3, 2025

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Bemcentinib

Bemcentinib capsules will be administered orally.

DRUG

Pembrolizumab

Pembrolizumab will be administered as an intravenous (IV) infusion as part of CIT every 3 weeks.

DRUG

Pemetrexed

Pemetrexed will be administered as an IV infusion as part of CIT every 3 weeks.

DRUG

Carboplatin

Carboplatin will be administered as an IV infusion as part of CIT every 3 weeks up to 4 cycles. Each cycle = 21 days.

Trial Locations (34)

144

IFO Regina Elena, Rome

1083

Semmelweis University- Department of Pulmonology, Budapest

1121

Orszagos Koranyi Pulmonologiai Intezet, Budapest

6189

Centre Antoine Lacassagne, Nice

8000

Fejer County St. Gyorgy Hospital, Székesfehérvár

8035

Hospital Universitario Vall d'Hebron, Barcelona

8916

Hospital Universitari Germans Trias i Pujol, Badalona

10029

Icahn School of Medicine at Mount Sinai, New York

11528

General Hospital of Athens Alexandra, Department of the Clinical Therapeutics, Medical Oncology Unit, Athens

20090

Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin

20141

IRCCS - Istituto Europeo di Oncologia IEO, Milan

21201

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore

27710

Duke University Medical Center - Duke Cancer Center, Durham

28033

MD Anderson Cancer Center, Oncology service, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28046

Hospital Universitario La Paz, Madrid

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

37203

Tennessee Oncology PLLC, Nashville

40138

Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi, Bologna

41110

University General Hospital of Larissa, Oncology Clinic, Larissa

44277

Hôpital prive du Confluent SAS, Departement d'oncologie, Nantes

46009

Fundacion Instituto Valenciano de Oncologia (FIVO), Valencia

46010

Hospital Clinico Universitario de Valencia, Valencia

55100

Ospedale San Luca, Lucca

60637

University of Chicago, Chicago

60693

MedPolonia Sp z oo, Poznan

75015

Hôpital Europeen Georges Pompidou (HEGP), Service de cancérologie, Paris

75390

UT Southwestern Medical Center, Dallas

94805

Institut Gustave Roussy, Service de médecine, Villejuif

115 26

Henry Dunant Hospital Center, 4th Oncology Department, Athens

115 27

Sotiria General Hospital of Chest Diseases, 3rd Department of Internal Medicine, Oncology Unit, Athens

15-540

Uniwersytecki Szpital Kliniczny w Bialymstoku, II Klinika Chorob Pluc, raka płuca i chorób wewnętrznych, Bialystok

93-338

Instytut Centrum Zdrowia Matki Polki (ICZMP), Lodz

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BerGenBio ASA

INDUSTRY

NCT05469178 - A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene | Biotech Hunter | Biotech Hunter