A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

210

Participants

Timeline

Start Date

August 10, 2022

Primary Completion Date

July 21, 2026

Study Completion Date

July 21, 2026

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Belzutifan

40 mg tablet administered orally at a dose of 120 mg.

DRUG

Palbociclib

75, 100, or 125 mg tablet administered orally according to randomized dose for 21 days consecutive days followed by 7 days off.

Trial Locations (13)

2109

Macquarie University-MQ Health Clinical Trials Unit ( Site 2001), Macquarie University

2145

Westmead Hospital ( Site 2006), Westmead

3199

Frankston Hospital-Oncology and Haematology ( Site 2005), Frankston

6009

One Clinical Research ( Site 2008), Nedlands

20007

Georgetown University Medical Center ( Site 1002), Washington D.C.

60637

University of Chicago Medical Center ( Site 1007), Chicago

84112

Huntsman Cancer Institute-HCI Clinical Trials Office ( Site 1004), Salt Lake City

1834111

Emek Medical Center-oncology ( Site 3003), Afula

3109601

Rambam Health Care Campus-Oncology ( Site 3000), Haifa

4941492

Rabin Medical Center-Oncology ( Site 3004), Petah Tikva

6423906

Sourasky Medical Center ( Site 3005), Tel Aviv

9103102

Shaare Zedek Medical Center-Oncology ( Site 3002), Jerusalem

02215

Beth Israel Deaconess Medical Center-Cancer Clinical Trials Office ( Site 1001), Boston

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY