Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
Thyroid Cancer
Interventions
DRUG

metformin

Metformin will be used 3 times a day (3x500mg), starting in the first week with 1x1 tablet (1x500 mg for breakfast), in the second week, 2x1 tablet (500 mg for breakfast and 500 mg for dinner), from the 3rd week 3x1 tablet. (3x500mg with main meals). A gradual escalation of the dose is planned to the point of developing drug intolerance or toxicity that is unacceptable to the patient.

RADIATION

Radioactive iodine (I-131)

Patients qualified to receive 131I treatment

Trial Locations (1)

15-276

Department of Endocrinology, Diabetology and Internal Medicine, Medical Univeristy of Bialystok, Bialystok

Sponsors
All Listed Sponsors
collaborator

Medical Research Agency, Poland

OTHER_GOV

lead

Medical University of Bialystok

OTHER

NCT05468554 - Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer | Biotech Hunter | Biotech Hunter