ChiCGB vs BEAM in High-risk or R/R Lymphomas

PHASE3RecruitingINTERVENTIONAL
Enrollment

306

Participants

Timeline

Start Date

July 1, 2022

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
Lymphoma, Large B-Cell, DiffuseLymphoma, T-Cell
Interventions
DRUG

Chidamide

30 mg oral twice weekly for 2 weeks

DRUG

Cladribine

6 mg/m2 intravenously once daily @ Day -7 \~ -3

DRUG

Gemcitabine

2500 mg/m2 intravenously @ Day -7, -3

DRUG

Busulfan

3.2 mg/kg intravenously once daily @ Day -7 \~ -4

DRUG

Carmustine

300 mg/m2 intravenously @ Day -8

DRUG

Etoposide

200 mg/m2 intravenously once daily @ Day -7 \~ -4

DRUG

Cytarabine

400 mg/m2 intravenously once daily @ Day -7 \~ -4

DRUG

Melphalan

140 mg/m2 intravenously @ Day -3

PROCEDURE

Autologous hematopoietic stem cell transplant

autologous hematopoietic stem cells infusion after ChiCGB or BEAM chemotherapy

Trial Locations (11)

610015

NOT_YET_RECRUITING

Chengdu Third People's Hospital, Chengdu

610041

RECRUITING

West China Hospital, Sichuan University, Chengdu

610071

RECRUITING

Chengdu First People's Hospital, Chengdu

610083

RECRUITING

PLA Western Theater Command General Hospital, Chengdu

618000

NOT_YET_RECRUITING

People's Hospital of Deyang City, Deyang

621000

RECRUITING

Central Hospital of Mianyang City, Mianyang

628099

RECRUITING

Guangyuan Central Hospital, Guangyuan

635000

NOT_YET_RECRUITING

Dazhou Central Hospital, Dazhou

637000

NOT_YET_RECRUITING

Affiliated Hospital of North Sichuan Medical College, Nanchong

643011

RECRUITING

Zigong First People's Hospital, Zigong

646000

RECRUITING

Southwest Medical University, Luzhou

All Listed Sponsors
lead

Sichuan University

OTHER