Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 1, 2021

Primary Completion Date

June 1, 2025

Study Completion Date

June 1, 2025

Conditions
Opioid UseOpioid DependenceOpioid-use DisorderNarcotic UseBack PainBack InjuriesChronic PainChronic Low-back PainPain, ChronicPain;Back Low;ChronicPain, Back
Interventions
DRUG

Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet

Subjects will receive a single dose of carbidopa/levodopa, when applicable.This will be double-blinded, as neither participants nor study staff will know what medication the participant is receiving.

DRUG

Naproxen 500 Mg

Subjects will receive a single dose of naproxen 500mg alongside carbidopa/levodopa, when applicable.This will be double-blinded, as neither participants nor study staff will know what medication the participant is receiving.

DRUG

Opioids

Subjects will be pre-screened in regards to their opioid medication. They will receive a single dose of their opioid dose, when appropriate. This will be double-blinded, as neither participants nor study staff will know what medication the participant is receiving.

Trial Locations (1)

60611

Northwestern University Feinberg School of Medicine, Chicago

All Listed Sponsors
collaborator

Shirley Ryan AbilityLab

OTHER

collaborator

National Institutes of Health (NIH)

NIH

lead

Northwestern University

OTHER