A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

June 21, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Alzheimer's DiseaseProdromal Alzheimer's DiseaseAmyloid PlaqueBeta-AmyloidAlzheimer's Disease in Down Syndrome
Interventions
BIOLOGICAL

Placebo

Administration of Placebo

BIOLOGICAL

ACI-24.060 at Dose A

Administration of Dose A of ACI-24.060

BIOLOGICAL

ACI-24.060 at Dose B

Administration of Dose B of ACI-24.060

BIOLOGICAL

ACI-24.060 at Dose C

Administration of Dose C of ACI-24.060

BIOLOGICAL

ACI-24.060 at Dose D

Administration of Dose D of ACI-24.060

BIOLOGICAL

Placebo

Administration of Placebo

BIOLOGICAL

ACI-24.060 at Dose X

Administration of Dose X of ACI-24.060. Dose X will be a dose already tested in Study Part 1

BIOLOGICAL

ACI-24.060 at Dose Y

Administration of Dose Y of ACI-24.060

Trial Locations (19)

46202

RECRUITING

Indiana University / IU Health, Indianapolis

63130

RECRUITING

The Washington University, St Louis

78229

RECRUITING

UT Health San Antonio, San Antonio

85013

RECRUITING

Barrow Neurological Institute, Phoenix

66205-2513

RECRUITING

University of Kansas Medical Center Research Institute, Fairway

02114

RECRUITING

Massachusetts General Hospital, Boston

37232-2103

RECRUITING

Vanderbilt University Medical Center, Nashville

Unknown

RECRUITING

Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

WITHDRAWN

Hospital Universitario Virgen De Las Nieves, Granada

RECRUITING

Hospital Clínico San Carlos, Madrid

RECRUITING

Hospital Universitario de la Princesa, Madrid

RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

RECRUITING

Hospital Universitario y Politécnico La Fe, Valencia

RECRUITING

Cambridge and Peterborough NHS Foundation Trust - Windsor Research Units, Cambridge

RECRUITING

Liverpool University Hospitals NHS Foundation Trust, Liverpool

RECRUITING

Re:Cognition Health Limited, London

RECRUITING

South London and Maudsley NHS Foundation Trust of The Maudsley Hospital, London

RECRUITING

Oxford Health NHS Foundation Trust, Oxford

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Worldwide Clinical Trials

OTHER

lead

AC Immune SA

INDUSTRY