Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

October 3, 2022

Primary Completion Date

February 26, 2024

Study Completion Date

February 26, 2024

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Sitravatinib

100 mg orally once daily

DRUG

Tislelizumab

200 mg intravenously once every 3 weeks

DRUG

Docetaxel

75 milligrams per square meter of body surface area (mg/m2) intravenously on Day 1 of every 21-day cycle

DRUG

Irinotecan

125 mg/m2 intravenously on Days 1 and 8 of every 21-day cycle

Trial Locations (31)

100050

Beijing Friendship Hospital, Capital Medical University, Beijing

100142

Beijing Cancer Hospital, Beijing

101149

Beijing Luhe Hospital, Capital Medical University, Beijing

110042

Liaoning Cancer Hospital and Institute, Shenyang

130021

Jilin Cancer Hospital, Changchun

150000

Harbin Medical University Cancer Hospital, Harbin

200025

Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai

200032

Affiliated Zhongshan Hospital of Fudan University, Shanghai

225001

Northern Jiangsu Peoples Hospital, Yangzhou

230036

Anhui Provincial Hospital South Brance, Hefei

230088

Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital, Hefei

250117

Shandong Cancer Hospital, Jinan

261000

Weifang Peoples Hospital, Weifang

300052

Tianjin Medical University General Hospital, Tianjin

310022

Zhejiang Cancer Hospital, Hangzhou

330006

The First Affiliated Hospital of Nanchang University Branch Donghu, Nanchang

341000

Ganzhou Peoples Hospital Ganzhou Hospital Affiliated to Nanchang University, Ganzhou

350005

The First Affiliated Hospital of Fujian Medical University, Fuzhou

350014

Fujian Cancer Hospital, Fuzhou

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

441021

Xiangyang Central Hospital, Xiangyang

450000

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

453100

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

510060

Sun Yat Sen University Cancer Center, Guangzhou

510700

Sun Yat Sen University Cancer Center(Huangpu Campus), Guangzhou

515031

Cancer Hospital of Shantou University Medical College, Shantou

530021

The Tumor Hospital Affiliated to Guangxi Medical University, Nanning

610041

West China Hospital, Sichuan University, Chengdu

610071

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT05461794 - Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma | Biotech Hunter | Biotech Hunter