Cognitive Effects and Potential Mechanisms of TBS in Subjects With MCI

NAEnrolling by invitationINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

September 13, 2022

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2025

Conditions
Mild Cognitive Impairment
Interventions
DEVICE

TBS for Amyloid-positive MCI

The investigators will perform standard intermittent TBS (iTBS) parameters to left DLPFC of every patient in the study. The frequency parameters of TBS are 3-pulse 50-Hz bursts, every 200 ms at 5 Hz, and the intensity is 90% of active motor threshold. A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times. In this study, The investigators will give two sessions of iTBS separated by 15 min.

DEVICE

TBS for Amyloid-negative MCI

The investigators will perform standard intermittent TBS (iTBS) parameters to left DLPFC of every patient in the study. The frequency parameters of TBS are 3-pulse 50-Hz bursts, every 200 ms at 5 Hz, and the intensity is 90% of active motor threshold. A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times. In this study, The investigators will give two sessions of iTBS separated by 15 min.

Trial Locations (1)

Unknown

Chang Gung Memorial Hospital, Taoyuan District

All Listed Sponsors
lead

Chang Gung Memorial Hospital

OTHER