Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer (MK-4830-002)

PHASE2CompletedINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

July 25, 2022

Primary Completion Date

December 20, 2023

Study Completion Date

October 16, 2024

Conditions
High-grade Serous Ovarian CarcinomaOvarian Carcinoma
Interventions
BIOLOGICAL

Pembrolizumab

200 mg by IV infusion on Day 1 of each 21-day cycle

DRUG

Paclitaxel

175 mg/m\^2 by IV infusion on Day 1 of each 21-day cycle

DRUG

Carboplatin

AUC 5 to 6 by IV infusion on Day 1 of each 21-day cycle

BIOLOGICAL

Avastin

According to local practice and at the choice of the investigator.

BIOLOGICAL

MK-4830

800 mg by IV infusion on Day 1 of each 21-day cycle

DRUG

Docetaxel

75 mg/m\^2 by IV infusion on Day 1 of each 21-day cycle

Trial Locations (45)

407

Taichung Veterans General Hospital-GYNECOLOGY ( Site 1202), Taichung

704

National Cheng Kung University Hospital ( Site 1201), Tainan City

2650

Antwerp University Hospital-Oncology ( Site 1301), Edegem

3000

UZ Leuven ( Site 1300), Leuven

9000

AZ Maria Middelares-IKG ( Site 1302), Ghent

10002

National Taiwan University Hospital-Internal Medicine ( Site 1200), Taipei

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0107), New York

10065

Memorial Sloan Kettering Cancer Center ( Site 0102), New York

10449

Mackay Memorial Hospital ( Site 1204), Taipei

11501

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0116), Mineola

14263

Roswell Park Cancer Institute ( Site 0106), Buffalo

20133

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 050, Milan

20141

Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 0501), Milan

28041

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1104), Madrid

32224

Mayo Clinic in Florida ( Site 0101), Jacksonville

33176

Miami Cancer Institute at Baptist Health, Inc. ( Site 0110), Miami

50006

Changhua Christian Hospital-Obstetrics and Gynecology ( Site 1203), Changhua County

57104

Sanford Cancer Center-Gynecologic Oncology ( Site 0115), Sioux Falls

60611

Northwestern Memorial Hospital ( Site 0104), Chicago

63110

Washington University ( Site 0113), St Louis

80045

University of Colorado Anschutz Medical Campus-Cancer Clinical Trials Office ( Site 0108), Aurora

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 0, Napoli

98109

Fred Hutchinson Cancer Center ( Site 0100), Seattle

119074

National University Hospital ( Site 1502), Singapore

168583

National Cancer Centre Singapore ( Site 1501), Singapore

2520598

ONCOCENTRO APYS-ACEREY ( Site 0904), Viña del Mar

3109601

Rambam Health Care Campus-Gyneco-oncology unit ( Site 0602), Haifa

4800827

James Lind Centro de Investigación del Cáncer ( Site 0903), Temuco

5265601

Sheba Medical Center-ONCOLOGY ( Site 0600), Ramat Gan

7500921

FALP ( Site 0905), Santiago

8330032

Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0900), Santiago

9103102

Shaare Zedek Medical Center ( Site 0601), Jerusalem

08901

Rutgers Cancer Institute of New Jersey ( Site 0114), New Brunswick

H2X 3E4

Centre Hospitalier de l'Université de Montréal ( Site 0300), Montreal

H4A 3J1

McGill University Health Centre ( Site 0301), Montreal

oo168

Fondazione Policlinico Universitario Agostino Gemelli-Ginecologia Oncologica ( Site 0502), Rome

61-848

Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 0709), Poznan

08-110

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0701), Siedlce

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Sit, Warsaw

80-214

Uniwersyteckie Centrum Kliniczne-Klinika Ginekologii, Ginekologii Onkologicznej i Endokrynologii Gi, Gdansk

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 0708), Kielce

03080

Seoul National University Hospital ( Site 0801), Seoul

03722

Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 0800), Seoul

08907

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Medical Oncology ( Site 1103), Hospitalet

08035

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1101), Barcelona

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY