Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

December 6, 2022

Primary Completion Date

November 4, 2024

Study Completion Date

November 30, 2027

Conditions
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Interventions
DRUG

JDQ443

JDQ443 per os (PO) 200 mg twice a day continuously

Trial Locations (44)

3200

Novartis Investigative Site, Mátraháza

8800

Novartis Investigative Site, Roeselare

9100

Novartis Investigative Site, Sint-Niklaas

10043

Novartis Investigative Site, Orbassano

10450

Novartis Investigative Site, George Town

10700

Novartis Investigative Site, Bangkok

11526

Novartis Investigative Site, Athens

13915

Novartis Investigative Site, Marseille

20089

Novartis Investigative Site, Rozzano

21075

Novartis Investigative Site, Hamburg

21280

Novartis Investigative Site, Diyarbakır

26121

Novartis Investigative Site, Oldenburg

28041

Novartis Investigative Site, Madrid

34070

Novartis Investigative Site, Montpellier

34214

Novartis Investigative Site, Istanbul

44805

Novartis Investigative Site, Saint-Herblain

67091

Novartis Investigative Site, Strasbourg

69677

Novartis Investigative Site, Bron

70124

Novartis Investigative Site, Bari

72076

Novartis Investigative Site, Tübingen

87439

Novartis Investigative Site, Kempten

93586

Novartis Investigative Site, Kuching

100036

Novartis Investigative Site, Beijing

221005

Novartis Investigative Site, Varanasi

410013

Novartis Investigative Site, Changsha

430030

Novartis Investigative Site, Wuhan

686016

Novartis Investigative Site, Thellakom Kottayam

02903

The Brown University Oncology Group, Providence

B1629AHJ

Novartis Investigative Site, Pilar

C1426AGE

Novartis Investigative Site, Buenos Aires

X5000JHQ

Novartis Investigative Site, Córdoba

X5016KEH

Novartis Investigative Site, Córdoba

A 6807

Novartis Investigative Site, Feldkirch

A-4600

Novartis Investigative Site, Wels

41825-010

Novartis Investigative Site, Salvador

30360 680

Novartis Investigative Site, Belo Horizonte

06120

Novartis Investigative Site, Halle

00128

Novartis Investigative Site, Roma

4818 CK

Novartis Investigative Site, Breda

8934 AD

Novartis Investigative Site, Leeuwarden

4100-180

Novartis Investigative Site, Porto

08035

Novartis Investigative Site, Barcelona

06500

Novartis Investigative Site, Ankara

TQ2 7AA

Novartis Investigative Site, Torquay

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY