Study to Assess the Effect of Co-Administration of AZD9833 on the Pharmacokinetics of Midazolam, of Omeprazole, of Celecoxib and of Dabigatran Etexilate in Healthy Postmenopausal Female Volunteers

PHASE1CompletedINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

June 13, 2022

Primary Completion Date

December 13, 2022

Study Completion Date

December 13, 2022

Conditions
Healthy Volunteers
Interventions
DRUG

AZD9833

AZD9833 tablets will be administered orally once daily on Days 1 - Day 5 (Treatment Period 2) and Day 1 (Treatment Period 3) for participants recruited to Arms A and C and Day 1 for those in Arm B

DRUG

Midazolam

Midazolam will be administered orally as a syrup once on Day 1 of Treatment Periods 1 and 3; administered together with Omeprazole

DRUG

Omeprazole

An Omeprazole capsule will be administered once on Day 1 of Treatment Periods 1 and 3; administered together with Midazolam

DRUG

Dabigatran Etexilate

A Dabigatran Etexilate capsule will be administered once on Day 1 of Treatment Periods 1 and 2

DRUG

Celecoxib

A Celecoxib capsule will be administered once on Day 1 of Treatment Periods 1 and 3

Trial Locations (2)

90806

Research Site, Long Beach

08009

Research Site, Berlin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY