A Study to Evaluate the Safety and Tolerability of AZD7442 in Healthy Chinese Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

October 9, 2021

Primary Completion Date

November 27, 2021

Study Completion Date

January 16, 2023

Conditions
Coronavirus Disease 2019 (COVID-19)Healthy Volunteer
Interventions
DRUG

AZD7442 IM

In cohort 1, participants will be randomized to receive 300 mg AZD7442 (150 mg AZD8895 and 150 mg AZD1061) administered sequentially as direct gluteal IM injections.

DRUG

Placebo IM

In cohort 1, participants will be randomized to receive placebo with dose match to AZD7442 in the same cohort administered sequentially as direct gluteal IM injections.

DRUG

AZD7442 IM

In cohort 2, participants will be randomized to receive 600 mg AZD7442 (300 mg AZD8895 and 300 mg AZD1061) administered sequentially as direct gluteal IM injections.

DRUG

Placebo IM

In cohort 2, participants will be randomized to receive placebo with dose match to AZD7442 in the same cohort administered sequentially as direct gluteal IM injections.

DRUG

AZD7442 IV

In cohort 3, participants will be randomized to receive 300 mg AZD7442 (150 mg AZD8895 and 150 mg AZD1061) mixed in IV bag co-administered as a single IV infusion.

DRUG

Placebo IV

In cohort 3, participants will be randomized to receive placebo with dose match to AZD7442 in the same cohort as a single IV infusion.

DRUG

AZD7442 IV

In cohort 4, participants will be randomized to receive 600 mg AZD7442 (300 mg AZD8895 and 300 mg AZD1061) mixed in IV bag co-administered as a single IV infusion.

DRUG

Placebo IV

In cohort 4, participants will be randomized to receive placebo with dose match to AZD7442 in the same cohort as a single IV infusion.

Trial Locations (2)

201107

Research Site, Shanghai

510515

Research Site, Guangzhou

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY