Low-dose Naltrexone for Post-COVID Fatigue Syndrome

PHASE2RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

January 15, 2024

Primary Completion Date

August 16, 2025

Study Completion Date

August 16, 2025

Conditions
Post-Viral Fatigue Syndrome
Interventions
DRUG

Low-Dose Naltrexone

"Study drug dosing schedule (LDN):~* Week 1: 1 mg/day (1 mg cap)~* Week 2: 2 mg/day (two 1 mg caps)~* Week 3: 3 mg/day (three 1mg caps)~* Weeks 4-6: 4.5 mg/day (three 1 mg caps, plus one 1.5 mg cap = 4.5 mg/day)~* Weeks 7-16: 4.5 mg/day (one 4.5 mg cap) OR based on self-titration dosage (one 1mg, 2mg, or 3mg cap)"

OTHER

Placebo

"Study drug dosing schedule (Placebo; capsules made to match LDN doses):~* Week 1: 1 mg/day (1 mg cap)~* Week 2: 2 mg/day (two 1 mg caps)~* Week 3: 3 mg/day (three 1mg caps)~* Weeks 4-6: 4.5 mg/day (three 1 mg caps, plus one 1.5 mg cap = 4.5 mg/day)~* Weeks 7-16: 4.5 mg/day (one 4.5 mg cap) OR based on self-titration dosage (one 1mg, 2mg, or 3mg cap)"

Trial Locations (1)

V6H 3N1

RECRUITING

Women's Health Research Institute, Vancouver

All Listed Sponsors
collaborator

University of British Columbia

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Provincial Health Services Authority

OTHER

collaborator

Women's Health Research Institute of British Columbia

OTHER

lead

Luis Nacul

OTHER